D1–D3: Asunción → D4–D5: Encarnación and Jesuit Mission Ruins → D6–D7: Ciudad del Este and the Triple Border. Asunción to Encarnación is about 370 km, taking 5–6 hours by long-distance bus; from Encarnación north to Ciudad del Este takes about 6 hours, or you can return to Asunción and transfer.
After landing at Silvio Pettirossi International Airport, head into the city. In the afternoon, stroll along the Riverside Boulevard, see the López Palace and the Heroes’ Pantheon, and in the evening, sample chipa and grilled meat at Mercado 4, experiencing the city’s vibrant street life.
In the morning, visit the Museum of the Casa de la Independencia and the Paraguay Cathedral. In the afternoon, go to Areguá to see ñandutí lace workshops and the lakeside town, then return to the city center in the evening to watch the sunset along the Riverside Boulevard.
Head to San Bernardino by Lake Ypacaraí. Go boating on the lake, try local fish dishes, and take an afternoon stroll through nearby towns – this is Asunción residents’ favorite weekend getaway.
On D6, head north to Ciudad del Este, explore duty-free malls and the electronics market. On D7, visit the Triple Border landmark to see where the Paraná and Iguazú Rivers meet, and optionally cross into Brazil to see the Iguazú Falls on the Brazilian side. Then depart via the Foz do Iguaçu Airport.